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Understanding it well means holding two things in mind at once: a genuinely novel and mechanistically interesting pharmacology, and an evidence base that is still maturing

Some of these events have been reported in patients without known underlying renal disease

86 Some evidence suggests individuals with MTHFR polymorphisms may need higher doses of folic acid to experience therapeutic benefits and may respond better to supplementation with 5-methyltetrahydrofolate (5-MTHF), the active form of this B vitamin

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